L-Levodopa (Fermentation)
Product Introduction-----L-Levodopa(L-DOPA)
L-Levodopais produced by method of Fermentation process which is a green and environmental line. It can be better to relief the environment press than chemical synthesis.
Product specification-----L-Levodopa(L-DOPA)
Item | Standard |
Appearance | White to slightly cream coloured, crystalline powder |
Identification | A.IR |
B.Chemical reaction | |
C.Chemical reaction | |
D.Chemical reaction | |
Solubility | Slightly soluble in water,pratically insoluble in alcohol and in ether,freely soluble in 1M hydrochloric acid and sparingly soluble in 0.1M hydrochloric acid. |
Appearance of solution | Not more intensely coloured than reference solution BY6 |
pH | 4.5~7.0 |
Related substances | Single impurity ≤0.5% |
Specific rotation | -1.27°~-1.34° |
Bulk density | ≥0.40gm/cc |
Tapped Density | ≥0.60gm/cc |
Loss on drying | Not more than 1.0% |
Particle size | 100% pass through 80 mesh |
Heavy metals | Not more than 10ppm |
Mercury | Not more than 0.1ppm |
Arsenic(As) | Not more than 1ppm |
Lead | Not more than 3ppm |
Iron(Fe) | Not more than 10ppm |
Cadmium | Not more than 1ppm |
Ash | Not more than 0.1ppm |
Assay | 99.0%~101.0% |
GMO/BSE Status | Not genetically modified organism. Free of BSE. |
Storage | Store in tight containers,in a cool dry area. |
Introduction:
l-DOPA, also known as levodopa and l-3,4-dihydroxyphenylalanine, is an amino acid that is made and used as part of the normal biology of some plants and animals, including humans. Humans, as well as a portion of the other animals that utilize l-DOPA, make it via biosynthesis from the amino acid l-tyrosine. l-DOPA is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), which are collectively known as catecholamines. Furthermore, levodopa itself mediates neurotrophic factor release by the brain and CNS. levodopa can be manufactured and in its pure form is sold as a psychoactive drug with the INN levodopa;As a drug, it is used in the clinical treatment of Parkinson's disease and dopamine-responsive dystonia.
Function:
Levodopa is the precursor to dopamine. Most commonly, clinicians use levodopa as a dopamine replacement agent for the treatment of Parkinson disease. It is most effectively used to control bradykinetic symptoms apparent in Parkinson disease. The drug can also be used for postencephalitic parkinsonism and symptomatic parkinsonism due to carbon monoxide intoxication.
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